Investigating how olfactory receptors affect blood pressure regulation
Olfactory Receptor 558 (OLFR558) Ligands and Blood Pressure Regulation
This study is looking at how a specific smell receptor in the body, called OLFR558, affects blood pressure differently in men and women, and it aims to find out what natural substances activate this receptor to help us better understand blood pressure control.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11010766 on NIH RePORTER |
What this research studies
This research explores the role of the olfactory receptor OLFR558 in regulating blood pressure, particularly focusing on how it differs between sexes. The study aims to identify the natural ligands that activate OLFR558 and understand their effects on blood pressure in both male and female mice. By examining these ligands, researchers hope to clarify how OLFR558 contributes to blood pressure homeostasis and the physiological differences observed between genders. This could lead to new insights into blood pressure regulation mechanisms and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with hypertension or those interested in understanding blood pressure regulation, especially premenopausal females.
Not a fit: Patients who do not have issues with blood pressure regulation or those who are not premenopausal females may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing blood pressure, particularly for individuals affected by hypertension.
How similar studies have performed: Previous research has shown promising results in understanding the role of olfactory receptors in physiological processes, suggesting potential for success in this novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Pluznick, Jennifer L — Johns Hopkins University
- Study coordinator: Pluznick, Jennifer L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.