Investigating how obscurin and Obsl1 affect heart function
The role of obscurin and Obsl1 as key determinants for diastolic function
This study is looking at how certain proteins in the heart affect its ability to relax and fill with blood, which is important for people with heart failure, especially those who also have conditions like diabetes or obesity, to help find new treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10766184 on NIH RePORTER |
What this research studies
This research focuses on understanding the roles of obscurin and Obsl1 proteins in heart function, particularly in relation to diastolic dysfunction, which is a key feature of heart failure with preserved ejection fraction (HFpEF). The study utilizes a novel genetic mouse model to explore how the absence of these proteins impacts cardiac physiology, metabolism, and calcium cycling. By examining these mechanisms, the research aims to identify potential pathways that could lead to new treatment options for patients suffering from heart failure. The findings may help clarify the complex interactions between heart function and various comorbidities such as diabetes and obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with heart failure, especially those experiencing diastolic dysfunction and related comorbidities.
Not a fit: Patients with heart failure who do not exhibit diastolic dysfunction or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating heart failure, particularly in patients with preserved ejection fraction.
How similar studies have performed: While the specific approach of targeting obscurin and Obsl1 is novel, similar studies have shown promise in understanding cardiac function and developing treatments for heart failure.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Cho, Yoshitake — University of California, San Diego
- Study coordinator: Cho, Yoshitake
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.