Investigating how obesity affects the response to metformin in endometrial cancer
Obesity-driven Metabolic and Molecular Biomarkers of Metformin Response in Endometrial Cancer
This study is looking at how the diabetes medication metformin might help treat endometrial cancer in people with obesity and diabetes, and it aims to find out which patients could benefit the most from this treatment.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10790007 on NIH RePORTER |
What this research studies
This research explores the relationship between obesity, diabetes, and endometrial cancer outcomes, focusing on how metformin, a diabetes medication, may help treat this cancer. The study examines the metabolic changes induced by metformin and its potential anti-cancer effects by analyzing gene expression patterns in tumors from obese and non-obese patients. By conducting a clinical trial, the researchers aim to identify specific biomarkers that predict which patients will respond best to metformin treatment, potentially leading to more personalized therapies for endometrial cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are obese patients diagnosed with endometrial cancer who are also managing type 2 diabetes.
Not a fit: Patients with endometrial cancer who are not obese or do not have diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for endometrial cancer patients, particularly those who are obese or have diabetes.
How similar studies have performed: Previous studies have shown promising results regarding the use of metformin in cancer treatment, indicating that this approach may be effective.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Bae-Jump, Victoria Lin — Univ of North Carolina Chapel Hill
- Study coordinator: Bae-Jump, Victoria Lin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.