Investigating how obesity affects protein quality control in endometrial cancer

Who could benefit from this research

What this research studies

This research explores the relationship between obesity and endometrial cancer (EC), focusing on how excess body weight may influence the effectiveness of protein quality control mechanisms in cancer cells. The study aims to understand the role of genetic mutations, particularly in the PI3K pathway, in the context of obesity and its impact on cancer development. By examining how obesity-induced stress affects cell survival and death in the uterus, the research seeks to uncover critical insights that could lead to better prevention and treatment strategies for EC in obese women.

Why it matters

Where this research is happening

• Wayne State University
  Detroit, United States Active

Researchers

• Principal investigator: Wilson, Michael R — Wayne State University
• Study coordinator: Wilson, Michael R

Related research

Other NIH-funded projects on the same topics.

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• How obesity affects cancer treatment in endometrial cancer patients

  This study is looking at how being overweight affects the success of certain cancer treatments for women with endometrial cancer, and it aims to find better ways to help those patients by combining two specific medications.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10672881

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• Understanding how maternal and infant sleep and daily rhythms influence early appetite and obesity risk

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  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11628798

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.