Investigating how obesity affects protein quality control in endometrial cancer
Does obesity influence protein quality control in endometrial cancer?
This study is looking at how being overweight might affect the way cancer cells in the uterus work, especially in women with endometrial cancer, to help find better ways to prevent and treat this type of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10980557 on NIH RePORTER |
What this research studies
This research explores the relationship between obesity and endometrial cancer (EC), focusing on how excess body weight may influence the effectiveness of protein quality control mechanisms in cancer cells. The study aims to understand the role of genetic mutations, particularly in the PI3K pathway, in the context of obesity and its impact on cancer development. By examining how obesity-induced stress affects cell survival and death in the uterus, the research seeks to uncover critical insights that could lead to better prevention and treatment strategies for EC in obese women.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are obese and at risk for developing endometrial cancer.
Not a fit: Patients who are not obese or do not have a risk of endometrial cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for endometrial cancer in women with obesity.
How similar studies have performed: Other research has indicated that understanding the interplay between obesity and cancer pathways can lead to significant advancements in cancer treatment, suggesting that this approach has potential for success.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Wilson, Michael R — Wayne State University
- Study coordinator: Wilson, Michael R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.