Investigating how obesity affects high blood pressure through specific cellular mechanisms
Official title: Obesity-related hypertension: the contribution of PPAR gamma acetylation and asprosin
Funded at New York Inst of Technology · NIH-10654210 · Data updated 2026-11-12
This study is looking at how being overweight can lead to high blood pressure by exploring how certain proteins and hormones in the body work, with the goal of finding better treatments for people who are obese and have hypertension.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Inst of Technology NIH-funded |
| Lab location | 1 site (Old Westbury, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $428,400 |
| NIH project number | 1R15HL165328-01A1 |
| Project ID | NIH-10654210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are obese and experiencing hypertension.
✕Less likely to help
Patients who are not obese or do not have hypertension may not benefit from this research.
What this research studies
This research explores the link between obesity and hypertension, focusing on how certain cellular processes, particularly the acetylation of a protein called PPAR gamma and the role of a newly identified hormone called asprosin, contribute to increased blood pressure in obese individuals. The study aims to understand how fat tissue around blood vessels affects their stiffness and function, which may lead to hypertension. By using both clinical and experimental methods, the research seeks to uncover the underlying mechanisms that could lead to targeted therapies for obese patients suffering from high blood pressure.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments specifically designed for managing hypertension in obese patients.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of obesity-related hypertension, but this specific approach focusing on PPAR gamma acetylation and asprosin is relatively novel.
Where this research is happening
-
New York Inst of Technology
Old Westbury, United States Active
Researchers
- Principal investigator: Carrillo-Sepulveda, Maria Alicia — New York Inst of Technology
- Study coordinator: Carrillo-Sepulveda, Maria Alicia
Related research
Other NIH-funded projects on the same topics.
-
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How brain signals link obesity to high blood pressure
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.