Investigating how obesity affects endometrial hyperplasia in postmenopausal women
Obesity-driven endometrial hyperplasia in postmenopausal women: Synergistic role for insulin and estrone
This study is looking at how being overweight might affect the risk of certain changes in the uterus that could lead to cancer in women after menopause, and it aims to find ways to help prevent this by understanding the role of hormones like insulin and estrone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10593167 on NIH RePORTER |
What this research studies
This research explores the relationship between obesity and the development of atypical endometrial hyperplasia (AEH) in postmenopausal women. It focuses on how elevated levels of insulin and estrone may contribute to changes in the endometrial tissue that could lead to cancer. By using mouse models, the study aims to identify specific histological changes and gene expression patterns associated with these hormonal influences. The findings could provide insights into prevention strategies for endometrial cancer linked to obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women who are obese and at risk for endometrial hyperplasia.
Not a fit: Patients who are not postmenopausal or who do not have obesity-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for endometrial cancer in obese postmenopausal women.
How similar studies have performed: Previous research has shown a strong correlation between obesity and endometrial cancer, indicating that this approach is built on established findings.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Flannery, Clare Ann — Yale University
- Study coordinator: Flannery, Clare Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.