Investigating how obesity affects breast cancer treatment response through fatty acid metabolism
Evaluating the impact of obesity associated fatty acid metabolic dysregulation on breast cancer sensitivity to ferroptosis
This study is looking at how being overweight might affect breast cancer treatment by changing the way the body processes fats, and it aims to find new ways to help improve treatment outcomes for people with breast cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11056676 on NIH RePORTER |
What this research studies
This research explores the relationship between obesity and breast cancer, focusing on how obesity-induced changes in fatty acid metabolism may influence the effectiveness of treatments that induce cell death in tumors. By using mouse models, the study aims to understand how excess fatty acids can fuel tumor growth and metastasis, potentially leading to new therapeutic strategies. The researchers will analyze tumor and blood samples to measure lipid levels and gene expression related to metabolism, providing insights into how these factors interact in the context of breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients who are also experiencing obesity.
Not a fit: Patients with breast cancer who are not obese or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for breast cancer patients, particularly those who are obese.
How similar studies have performed: While the specific approach of linking obesity, fatty acid metabolism, and ferroptosis in breast cancer is relatively novel, related research has shown promising results in understanding metabolic influences on cancer progression.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Devericks, Emily — Univ of North Carolina Chapel Hill
- Study coordinator: Devericks, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.