Investigating how obesity affects blood vessel function through Wnt signaling
Wnt signaling control of vascular phenotype in obesity
This study is looking at how obesity affects blood vessel health and is for people with obesity; it will help researchers understand the role of certain signals in causing problems like inflammation and insulin resistance by examining tissue samples from both obese and lean individuals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10666496 on NIH RePORTER |
What this research studies
This research explores the mechanisms behind vascular dysfunction in individuals with obesity, a condition affecting a significant portion of the population. By examining blood vessels and endothelial cells from both obese and lean subjects, the study aims to understand how Wnt signaling pathways contribute to issues like inflammation and insulin resistance. The approach combines clinical patient data with experimental techniques to provide insights into how obesity impacts cardiovascular health. Participants will undergo procedures that allow researchers to analyze their adipose tissue and blood vessels directly.
Who could benefit from this research
Good fit: Ideal candidates for this research include obese individuals who are undergoing elective surgical procedures and lean individuals matched by age and gender.
Not a fit: Patients who are not obese or do not have related cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve vascular health and reduce cardiovascular disease risk in obese patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of signaling pathways in obesity-related vascular dysfunction, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Gokce, Noyan — Boston University Medical Campus
- Study coordinator: Gokce, Noyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.