Investigating how obesity affects airway changes in asthma
Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma
This study is looking at how being overweight affects asthma and why people with both conditions often don’t get better with regular treatments, so we can find better ways to help them breathe easier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10690510 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of obesity on asthma, particularly how it leads to changes in the airways that can worsen the condition. It aims to explore why obese asthmatics do not respond well to standard asthma treatments and to identify specific areas of airway remodeling and fibrosis that are affected. By using advanced techniques to study these changes, the research seeks to bridge the gap between animal models and human patients, ultimately aiming to develop more effective therapies for this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with asthma who are also classified as obese.
Not a fit: Patients with asthma who are not obese may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for obese asthmatics, enhancing their quality of life and asthma management.
How similar studies have performed: While there has been limited research specifically on obese asthmatics, similar studies on obesity's impact on other respiratory conditions have shown promising results.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Que, Loretta G — Duke University
- Study coordinator: Que, Loretta G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.