Investigating how nutrients affect mitochondrial activity in Alzheimer's disease
Nutrient-Induced Mitochondrial Activity (NiMA): A Novel Lysosome to Mitochondria Signaling Pathway, its mechanisms and role in Alzheimer's Disease
This study is looking at how certain nutrients affect energy production in brain cells and how this relates to Alzheimer's disease, with the goal of finding new ways to help improve brain health for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10808080 on NIH RePORTER |
What this research studies
This research explores the connection between nutrient-induced mitochondrial activity and Alzheimer's disease by examining how amyloid-beta oligomers and tau proteins impact brain cell function. The study aims to understand the molecular mechanisms that lead to cognitive decline in Alzheimer's patients, particularly focusing on mitochondrial energy metabolism and insulin resistance in the brain. By analyzing these interactions, the research seeks to uncover potential therapeutic targets that could improve brain health in individuals affected by Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline related to aging.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance mitochondrial function and improve cognitive health in Alzheimer's patients.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in Alzheimer's disease, indicating that this approach may lead to significant advancements.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Norambuena, Andres M — University of Virginia
- Study coordinator: Norambuena, Andres M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.