Investigating how nutrient-sensing affects immune cells in aging
Nutrient-sensing GHS-R in macrophage reprogramming and inflamm-aging
This study is looking at how getting older can lead to more fat and inflammation in the body, and it’s specifically exploring how certain immune cells called macrophages behave in older adults; the goal is to find ways to change these cells to help reduce inflammation and improve health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project ID | NIH-10652564 on NIH RePORTER |
What this research studies
This research focuses on understanding how aging leads to increased fat tissue and chronic inflammation, a condition known as 'inflamm-aging.' It examines the role of macrophages, which are immune cells that can become either pro-inflammatory or anti-inflammatory, in this process. The study aims to explore how the growth hormone secretagogue receptor (GHS-R) influences the behavior of these macrophages, particularly in older adults, and how reprogramming these cells could help reduce inflammation associated with aging. By using advanced techniques to manipulate GHS-R in macrophages, the research seeks to uncover potential therapeutic strategies for age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related inflammation and associated health issues.
Not a fit: Patients who are younger or do not have inflammation-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve health outcomes for older adults.
How similar studies have performed: Previous research has shown promising results in targeting immune cell behavior to mitigate inflammation in aging, suggesting that this approach could be effective.
Where this research is happening
College Station, UNITED STATES
- Texas A&m Agrilife Research — College Station, United States (Active)
Researchers
- Principal investigator: Sun, Yuxiang — Texas A&m Agrilife Research
- Study coordinator: Sun, Yuxiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.