Investigating how Nurr1 interacts with Parkinson's disease risk factors and its regulation by specific compounds.
Crosstalk Between Nurr1 and Risk Factors of Parkinson's Disease and its Regulation by Nurr1's Ligands
['FUNDING_R01'] · MCLEAN HOSPITAL · NIH-11086085
This study is looking at a protein called Nurr1 to see how it affects the brain cells that produce dopamine in people with Parkinson's disease, and it hopes to find new ways to help slow down the disease by testing different natural and synthetic compounds that can boost Nurr1's activity.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MCLEAN HOSPITAL (nih funded) |
| Locations | 1 site (BELMONT, UNITED STATES) |
| Trial ID | NIH-11086085 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the Nurr1 protein in Parkinson's disease, particularly how it interacts with risk factors and is influenced by various compounds. Researchers will explore how Nurr1 affects the health of dopamine-producing neurons, which are crucial in Parkinson's disease. By identifying both synthetic and natural compounds that can activate Nurr1, the study aims to uncover new therapeutic strategies that could potentially slow down or halt disease progression. Patients may benefit from insights gained into how these interactions can be targeted for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Parkinson's disease or those at risk due to genetic or environmental factors.
Not a fit: Patients with Parkinson's disease who are already at advanced stages may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow or stop the progression of Parkinson's disease.
How similar studies have performed: Previous research has shown promise in targeting Nurr1 for therapeutic purposes, indicating potential for success in this approach.
Where this research is happening
BELMONT, UNITED STATES
- MCLEAN HOSPITAL — BELMONT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, KWANG-SOO — MCLEAN HOSPITAL
- Study coordinator: KIM, KWANG-SOO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.