Investigating how Nurr1 interacts with Parkinson's disease risk factors and its regulation by specific compounds.

Who could benefit from this research

What this research studies

This research focuses on understanding the role of the Nurr1 protein in Parkinson's disease, particularly how it interacts with risk factors and is influenced by various compounds. Researchers will explore how Nurr1 affects the health of dopamine-producing neurons, which are crucial in Parkinson's disease. By identifying both synthetic and natural compounds that can activate Nurr1, the study aims to uncover new therapeutic strategies that could potentially slow down or halt disease progression. Patients may benefit from insights gained into how these interactions can be targeted for treatment.

Why it matters

Where this research is happening

• Mclean Hospital
  Belmont, United States Active

Researchers

• Principal investigator: Kim, Kwang-Soo — Mclean Hospital
• Study coordinator: Kim, Kwang-Soo

Related research

Other NIH-funded projects on the same topics.

• How Nurr1 interacts with Parkinson's risk factors and how drugs or natural molecules might control it

  This project explores whether drugs and natural molecules that activate Nurr1 can help protect the dopamine-producing brain cells affected in Parkinson's disease.

  NIH research Mclean Hospital · Belmont, United States · NIH-11324951

• Markers and risk factors for early (prodromal) Parkinson's and how it progresses

  This project follows people with early signs of Parkinson's to find markers that predict who will go on to develop Parkinson's and how symptoms change over time.

  NIH research Harvard University D/b/a Harvard School of Public Health · Boston, United States · NIH-11317223

• Investigating early signs and risk factors for Parkinson's disease

  This study is looking at the early signs of Parkinson's disease to help understand how it develops, and it's for people who might be experiencing these early symptoms; participants will take some tests and surveys to help researchers find ways to prevent the disease in the future.

  NIH research Harvard School of Public Health · Boston, United States · NIH-11059852

• Gut-brain clues in Parkinson’s disease: supplement to a large registry

  A plant-wide supplement to an NIH program will enroll people with Parkinson’s, with and without GI symptoms, plus healthy controls, to study how gut function, brain signals, and sleep rhythms relate to Parkinson’s symptoms.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11612995

• P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetic, behavior, and vascular data

  Aims to predict Alzheimer’s disease risk in middle-aged South Asians by combining genetic, lifestyle, and vascular information to catch early changes before dementia develops.

  NIH research Emory University · Atlanta, United States · NIH-11604418

• P-CARRS-BRAIN: Predicting Alzheimer’s risk in South Asians in India using genetics, behavior, and vascular data

  Aimed at people 21 and older, this project looks at how biology, behavior, and blood vessel health together may signal the early risk of Alzheimer’s disease and related dementias in South Asians.

  NIH research Emory University · Atlanta, United States · NIH-11604417

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.