Investigating how nuclear receptors affect aging and age-related macular degeneration.
Nuclear receptor driven mechanisms in aging and AMD
This study is looking into how a specific protein might help us understand and treat age-related macular degeneration (AMD), a common cause of vision loss in older people, with the hope that it could lead to new treatments to help preserve eyesight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10887592 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind age-related macular degeneration (AMD), a leading cause of vision loss in older adults. It aims to explore the role of nuclear receptors, specifically NURR1, in the dysfunction of retinal pigment epithelial cells that contribute to AMD. By examining various biological processes such as inflammation and lipid metabolism, the study seeks to identify potential pathways that could lead to new treatments. Patients may benefit from insights that could eventually lead to drug development for AMD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing or at risk for age-related macular degeneration.
Not a fit: Patients under the age of 65 or those without any signs of age-related macular degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating age-related macular degeneration, potentially preserving vision in older adults.
How similar studies have performed: Previous research has shown promise in targeting nuclear receptors for various diseases, suggesting potential for success in this novel approach to AMD.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Malek, Goldis — Duke University
- Study coordinator: Malek, Goldis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.