Investigating how nuclear pore complexes affect prostate cancer aggressiveness
Role of Nuclear Pore-Regulated Mechanisms in Prostate Cancer Aggressiveness
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-10733422
This study is looking at how certain proteins in our cells might affect the growth and spread of advanced prostate cancer, with the goal of finding new ways to treat patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10733422 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of nuclear pore complexes (NPCs) in the progression of metastatic prostate cancer, particularly how they regulate gene expression and genome integrity. By using innovative pre-clinical models, the study aims to identify new targetable pathways that contribute to cancer aggressiveness. Researchers will analyze the expression of specific nucleoporins, which are proteins that make up NPCs, to uncover their involvement in tumor development and resistance to therapy. This could lead to new treatment strategies for patients with advanced prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic prostate cancer, particularly those who have developed resistance to current therapies.
Not a fit: Patients with early-stage prostate cancer or those who do not have metastatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that improve outcomes for patients with aggressive prostate cancer.
How similar studies have performed: Previous research has shown that targeting nucleoporins can be effective in cancer treatment, suggesting that this approach may yield promising results.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RODRIGUEZ-BRAVO, VERONICA — MAYO CLINIC ROCHESTER
- Study coordinator: RODRIGUEZ-BRAVO, VERONICA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer progression