Investigating how nuclear import receptors can help manage TDP-43 protein issues in neurodegenerative diseases
Nuclear import receptors as modifiers of TDP-43 phase transition and toxicity in FTD/ALS
['FUNDING_R01'] · MAYO CLINIC JACKSONVILLE · NIH-10982484
This study is looking at how certain proteins can help clear out harmful clumps of TDP-43 that are linked to diseases like frontotemporal dementia, ALS, and Alzheimer's, with the hope of finding new ways to help people affected by these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-10982484 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how nuclear import receptors (NIRs) can prevent and reverse the harmful accumulation of TDP-43 protein aggregates, which are linked to several neurodegenerative disorders, including frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The researchers will explore the mechanisms by which NIRs interact with TDP-43 and other proteins to restore their normal functions. By using cellular and animal models, they aim to identify potential therapeutic strategies that could mitigate the effects of these diseases on patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with frontotemporal dementia, amyotrophic lateral sclerosis, or Alzheimer's disease.
Not a fit: Patients with neurodegenerative disorders not associated with TDP-43 pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or reverse the progression of neurodegenerative diseases associated with TDP-43 pathology.
How similar studies have performed: Previous research has shown promise in targeting TDP-43 pathology, indicating that this approach could be a viable strategy for therapeutic intervention.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSSOLL, WILFRIED — MAYO CLINIC JACKSONVILLE
- Study coordinator: ROSSOLL, WILFRIED
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease and related dementia, Alzheimer's disease and related disorders