Investigating how nuclear import receptors can help manage TDP-43 protein issues in neurodegenerative diseases
Official title: Nuclear import receptors as modifiers of TDP-43 phase transition and toxicity in FTD/ALS
Funded at Mayo Clinic Jacksonville · NIH-10982484 · Data updated 2026-11-12
This study is looking at how certain proteins can help clear out harmful clumps of TDP-43 that are linked to diseases like frontotemporal dementia, ALS, and Alzheimer's, with the hope of finding new ways to help people affected by these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $648,262 |
| NIH project number | 5R01AG077771-03 |
| Project ID | NIH-10982484 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with frontotemporal dementia, amyotrophic lateral sclerosis, or Alzheimer's disease.
✕Less likely to help
Patients with neurodegenerative disorders not associated with TDP-43 pathology may not benefit from this research.
What this research studies
This research focuses on understanding how nuclear import receptors (NIRs) can prevent and reverse the harmful accumulation of TDP-43 protein aggregates, which are linked to several neurodegenerative disorders, including frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The researchers will explore the mechanisms by which NIRs interact with TDP-43 and other proteins to restore their normal functions. By using cellular and animal models, they aim to identify potential therapeutic strategies that could mitigate the effects of these diseases on patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or reverse the progression of neurodegenerative diseases associated with TDP-43 pathology.
How similar studies have gone: Previous research has shown promise in targeting TDP-43 pathology, indicating that this approach could be a viable strategy for therapeutic intervention.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Rossoll, Wilfried — Mayo Clinic Jacksonville
- Study coordinator: Rossoll, Wilfried
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.