Investigating how nuclear and glial cell functions are affected in neurodegenerative diseases.
Nuclear and Glial Dysfunction in Neurodegeneration
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11086019
This study is looking into how problems with cell transport and support cells in the brain might contribute to diseases like ALS and frontotemporal dementia, with the hope of finding new ways to help people who are affected by these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11086019 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of nuclear transport and glial cell dysfunction in neurodegenerative diseases such as ALS and frontotemporal dementia. By utilizing patient-derived induced pluripotent stem cells and various animal models, the study aims to uncover the mechanisms by which nuclear pore complexes are disrupted in these conditions. The research will explore potential therapeutic targets and pathways that could lead to new treatments for patients suffering from these debilitating diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ALS or frontotemporal dementia, particularly those with familial forms of these diseases.
Not a fit: Patients with neurodegenerative diseases unrelated to ALS or frontotemporal dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or halt the progression of ALS and frontotemporal dementia.
How similar studies have performed: Previous research has shown promising results in understanding neurodegenerative diseases through similar model systems, indicating a strong potential for success in this area.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROTHSTEIN, JEFFREY D — JOHNS HOPKINS UNIVERSITY
- Study coordinator: ROTHSTEIN, JEFFREY D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.