Investigating how nuclear and glial cell functions are affected in neurodegenerative diseases.
Official title: Nuclear and Glial Dysfunction in Neurodegeneration
Funded at Johns Hopkins University · NIH-11086019 · Data updated 2026-11-12
This study is looking into how problems with cell transport and support cells in the brain might contribute to diseases like ALS and frontotemporal dementia, with the hope of finding new ways to help people who are affected by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 16, 2023 |
| Project end | April 30, 2031 |
| Funding year | 2025 |
| Award (this year) | $1,228,125 |
| NIH project number | 5R35NS132179-03 |
| Project ID | NIH-11086019 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with ALS or frontotemporal dementia, particularly those with familial forms of these diseases.
✕Less likely to help
Patients with neurodegenerative diseases unrelated to ALS or frontotemporal dementia may not benefit from this research.
What this research studies
This research focuses on understanding the role of nuclear transport and glial cell dysfunction in neurodegenerative diseases such as ALS and frontotemporal dementia. By utilizing patient-derived induced pluripotent stem cells and various animal models, the study aims to uncover the mechanisms by which nuclear pore complexes are disrupted in these conditions. The research will explore potential therapeutic targets and pathways that could lead to new treatments for patients suffering from these debilitating diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or halt the progression of ALS and frontotemporal dementia.
How similar studies have gone: Previous research has shown promising results in understanding neurodegenerative diseases through similar model systems, indicating a strong potential for success in this area.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Rothstein, Jeffrey D — Johns Hopkins University
- Study coordinator: Rothstein, Jeffrey D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.