Investigating how NRF transcription factors respond to environmental stress and disease.
NRF Transcription Factors in Environmental Stress and Disease Intervention
This study is looking at how long-term exposure to arsenic, a harmful substance, affects our body's ability to handle stress at the cellular level, with the goal of finding better ways to protect against diseases like cancer and diabetes that can be linked to arsenic.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11074677 on NIH RePORTER |
What this research studies
This research focuses on understanding how chronic exposure to arsenic, a harmful environmental contaminant, affects the body's cellular stress response, particularly through the NRF2 signaling pathway. By exploring the mechanisms behind arsenic-induced diseases, including certain cancers and type II diabetes, the research aims to develop new therapeutic strategies that harness the body's natural defense systems. Patients may benefit from insights gained into how to mitigate the health impacts of arsenic exposure and improve treatment options for related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals exposed to arsenic and those at risk for arsenic-related diseases, such as certain cancers and type II diabetes.
Not a fit: Patients who have not been exposed to arsenic or do not have conditions related to arsenic exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect against diseases caused by environmental toxins like arsenic.
How similar studies have performed: Previous research has shown promise in targeting the NRF2 pathway for therapeutic interventions, indicating that this approach may yield beneficial results.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Zhang, Donna D — University of Florida
- Study coordinator: Zhang, Donna D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.