Investigating how Notch signaling affects osteoarthritis in the jaw joint.
Official title: Notch Signaling in the Regulation of TMJ Osteoarthritis
Funded at University of Nebraska Medical Center · NIH-10876539 · Data updated 2026-11-12
This study is looking at how a specific signaling process in the body affects the development of osteoarthritis in the jaw joint, with the goal of finding new ways to help reduce joint pain and cartilage damage for people with this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | June 22, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $133,999 |
| NIH project number | 7R03DE030226-03 |
| Project ID | NIH-10876539 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing symptoms of osteoarthritis in the temporomandibular joint.
✕Less likely to help
Patients with osteoarthritis in joints other than the temporomandibular joint may not benefit from this research.
What this research studies
This research focuses on understanding the role of Notch signaling in the development of osteoarthritis (OA) in the temporomandibular joint (TMJ). The study aims to explore how changes in the Notch signaling pathway influence cartilage degradation and joint pain associated with OA. By examining the molecular mechanisms involved, the researchers hope to identify potential targets for therapeutic intervention. The approach includes using animal models to observe the effects of specific genetic modifications on cartilage health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent cartilage breakdown in patients with TMJ osteoarthritis.
How similar studies have gone: Previous research has shown that targeting molecular pathways like Notch can yield promising results in other forms of osteoarthritis, suggesting potential for success in this area as well.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Yadav, Sumit — University of Nebraska Medical Center
- Study coordinator: Yadav, Sumit
Related research
Other NIH-funded projects on the same topics.
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-
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This grant asks researchers to find early, invisible clues of osteoarthritis subtypes so we can target treatments before joints are damaged.
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-
Aberrant mechano-oxygen coupling linked to zinc-rich mineralization in osteoarthritis
Aims to understand how abnormal joint forces affect cartilage and bone, causing zinc-rich mineral deposits and harmful blood vessel growth in osteoarthritis.
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Notch signaling in TMJ osteoarthritis: uncovering mechanisms and new targets
Researchers are studying how Notch signaling affects TMJ osteoarthritis to identify new ways to protect and repair the jaw joint.
-
Nanoparticles delivering an sPLA2 blocker for knee osteoarthritis
This project uses tiny, drug-filled nanoparticles to deliver an sPLA2-blocking medicine into the knee to reduce inflammation and slow knee osteoarthritis in people with painful knee OA.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.