Investigating how norepinephrine transporter changes affect amphetamine reward
The role of norepinephrine transporter phosphorylation in amphetamine reward
['FUNDING_R01'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-10859170
This study is looking at how the brain changes when someone uses amphetamines, especially during the COVID-19 pandemic, to find new ways to help people struggling with substance use disorder.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-10859170 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the neurobiology of substance use disorder (SUD) related to amphetamines, particularly in the context of the COVID-19 pandemic. It examines how the norepinephrine transporter (NET) is modified through phosphorylation and how these changes influence the rewarding effects of amphetamines. Using advanced techniques, including genetically modified mouse models and brain recordings, the study aims to uncover the mechanisms behind amphetamine's effects on behavior. By exploring these biological processes, the research seeks to identify potential new targets for effective treatments for SUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who are struggling with amphetamine use or related substance use disorders.
Not a fit: Patients who do not use amphetamines or are not affected by substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new medications for treating amphetamine-related substance use disorders.
How similar studies have performed: While the specific focus on NET phosphorylation in SUD is novel, previous research has shown promise in understanding neurobiological mechanisms related to substance use disorders.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAYANTHI, LANKUPALLE D — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: JAYANTHI, LANKUPALLE D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.