Investigating how norepinephrine transporter changes affect amphetamine reward
Official title: The role of norepinephrine transporter phosphorylation in amphetamine reward
Funded at Virginia Commonwealth University · NIH-10859170 · Data updated 2026-11-12
This study is looking at how the brain changes when someone uses amphetamines, especially during the COVID-19 pandemic, to find new ways to help people struggling with substance use disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | September 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $587,162 |
| NIH project number | 1R01DA060210-01 |
| Project ID | NIH-10859170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who are struggling with amphetamine use or related substance use disorders.
✕Less likely to help
Patients who do not use amphetamines or are not affected by substance use disorders may not benefit from this research.
What this research studies
This research focuses on understanding the neurobiology of substance use disorder (SUD) related to amphetamines, particularly in the context of the COVID-19 pandemic. It examines how the norepinephrine transporter (NET) is modified through phosphorylation and how these changes influence the rewarding effects of amphetamines. Using advanced techniques, including genetically modified mouse models and brain recordings, the study aims to uncover the mechanisms behind amphetamine's effects on behavior. By exploring these biological processes, the research seeks to identify potential new targets for effective treatments for SUD.
Why it matters
Potential benefit: If successful, this research could lead to the development of new medications for treating amphetamine-related substance use disorders.
How similar studies have gone: While the specific focus on NET phosphorylation in SUD is novel, previous research has shown promise in understanding neurobiological mechanisms related to substance use disorders.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Jayanthi, Lankupalle D — Virginia Commonwealth University
- Study coordinator: Jayanthi, Lankupalle D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.