Investigating how norepinephrine production changes with aging and Alzheimer's disease
Upregulated Norepinephrine Synthesis Capacity in Aging
This study is looking at how changes in a part of the brain that helps with attention and memory might affect the levels of a key chemical in older adults, especially those with mild cognitive issues or Alzheimer's, to see why some people can still think clearly as they age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project ID | NIH-11086624 on NIH RePORTER |
What this research studies
This research focuses on the locus coeruleus, a brain region that produces norepinephrine, which is crucial for attention and memory. It examines how the accumulation of abnormal tau protein, associated with Alzheimer's disease, affects norepinephrine synthesis in older adults. By studying the structural integrity of the locus coeruleus and its relationship with norepinephrine levels, the research aims to understand how some individuals may maintain cognitive function despite aging and neurodegeneration. The approach includes analyzing brain imaging and biochemical markers in healthy older adults and those with mild cognitive impairment or Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults aged 65 and above, particularly those experiencing mild cognitive impairment or early signs of Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving cognitive function in aging individuals and those at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of norepinephrine in cognitive function and neuroprotection, suggesting that this approach could yield valuable insights.
Where this research is happening
Waltham, United States
- Brandeis University — Waltham, United States (Active)
Researchers
- Principal investigator: Berry, Anne Shively — Brandeis University
- Study coordinator: Berry, Anne Shively
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.