Investigating how noncoding regions of the genome affect human diseases and evolution
Single-Cell Analysis of the Noncoding Genome in Human Diseases and Evolution
This study is looking at how certain genetic changes that don't code for proteins can affect diseases and evolution by examining individual cells, and it hopes to help patients understand the genetic factors behind their health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10875390 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of noncoding regulatory mutations in human diseases and evolution by analyzing the genome at a single-cell level. It aims to identify how these mutations influence gene regulation in specific cell types and developmental stages. By employing advanced machine learning techniques, the project seeks to map the effects of these mutations on cellular architecture, which could provide insights into disease mechanisms and evolutionary changes. Patients may benefit from a better understanding of the genetic factors contributing to their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders or diseases linked to noncoding mutations.
Not a fit: Patients with conditions unrelated to genetic mutations or those not involving noncoding regions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding the genetic basis of various diseases, potentially improving diagnosis and treatment options.
How similar studies have performed: Previous research has shown promise in understanding the role of noncoding regions in diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Li, Jingjing — University of California, San Francisco
- Study coordinator: Li, Jingjing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.