Investigating how non-tuberculous mycobacterium affects immune responses in tuberculosis.
Official title: Non-tuberculous mycobacterium and B cells in the stimulation of ectopic germinal centers and immunological control of pulmonary tuberculosis
Funded at Colorado State University · NIH-10895280 · Data updated 2026-11-12
This study is looking at how certain bacteria can help boost the immune system's fight against tuberculosis (TB) in the lungs, with the hope of finding better vaccines and treatments for people with TB.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $112,360 |
| NIH project number | 5K99AI173401-02 |
| Project ID | NIH-10895280 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals at risk for or currently suffering from pulmonary tuberculosis, especially those with multidrug-resistant TB.
✕Less likely to help
Patients who do not have tuberculosis or are not at risk for TB may not receive any benefit from this research.
What this research studies
This research explores the role of non-tuberculous mycobacterium in enhancing the immune response against pulmonary tuberculosis (TB). It focuses on how exposure to these bacteria can stimulate the formation of ectopic germinal centers in the lungs, which are crucial for generating a robust immune response. By studying the interactions between B cells and antigen-presenting cells, the research aims to identify new therapeutic strategies that could improve TB treatment and prevention. Patients may benefit from insights gained into more effective vaccines or therapies for TB.
Why it matters
Potential benefit: If successful, this research could lead to the development of improved vaccines or therapies for tuberculosis, particularly for those with drug-resistant strains.
How similar studies have gone: Previous research has shown promising results in enhancing immune responses through similar approaches, indicating potential for success in this area.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Dutt, Taru S. — Colorado State University
- Study coordinator: Dutt, Taru S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.