Investigating how non-coding RNAs help protect against Alzheimer’s Disease
Official title: Non-coding RNAs in resilience to Alzheimer’s Disease
Funded at Beth Israel Deaconess Medical Center · NIH-11043418 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in our genes might help some older people stay sharp and think clearly even when they have changes in their brains related to Alzheimer’s Disease, with the hope of finding ways to keep everyone’s mind healthy as they age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 15, 2023 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $827,394 |
| NIH project number | 5R01AG082093-03 |
| Project ID | NIH-11043418 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals who are cognitively healthy despite having Alzheimer’s-related brain changes.
✕Less likely to help
Patients who are already experiencing significant cognitive decline or have advanced Alzheimer's Disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of non-coding RNAs in enhancing resilience to Alzheimer’s Disease (AD). It aims to identify specific non-coding RNA regulators that help individuals maintain cognitive function despite the presence of AD-related brain changes. By studying a unique group of elderly individuals who remain cognitively intact, the research seeks to uncover mechanisms that could prevent cognitive decline. The approach involves analyzing gene expression and regulatory processes that are crucial for brain health as people age.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying cognitive decline in Alzheimer’s Disease.
How similar studies have gone: Previous research has shown promise in understanding the role of non-coding RNAs in various diseases, suggesting potential for success in this novel approach to Alzheimer’s Disease.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Slack, Frank J. — Beth Israel Deaconess Medical Center
- Study coordinator: Slack, Frank J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.