Investigating how non-coding RNA affects kidney disease progression
Non-Coding RNA and CKD Progression
This study is looking at how certain tiny RNA molecules in your blood and urine might help us spot early signs of kidney damage in people with chronic kidney disease, and we’d love for patients to help by sharing their samples and information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10670205 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of non-coding RNAs in kidney fibrosis, which is a key factor in the progression of chronic kidney disease (CKD). By analyzing blood and urine samples from participants with varying rates of CKD progression, the study aims to identify specific microRNAs and long non-coding RNAs that could serve as early biomarkers for kidney damage. The research will involve multiple phases, including discovery, replication, and experimental validation, utilizing advanced sequencing techniques and mouse models to explore the functional significance of these RNA molecules. Patients may be involved in providing biosamples and data to help uncover these important indicators of kidney health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease, particularly those experiencing varying rates of disease progression.
Not a fit: Patients with acute kidney injury or those without any kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of chronic kidney disease, potentially slowing its progression.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for kidney disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Raj, Dominic S — George Washington University
- Study coordinator: Raj, Dominic S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.