Investigating how non-coding DNA influences gene expression
Exploiting Natural Genetic and Organismic Variation to Identify the DNA Motifs Regulating Transcription
['FUNDING_OTHER'] · WASHINGTON STATE UNIVERSITY · NIH-10783066
This study is exploring how certain parts of our DNA that don't code for proteins help control how our genes work, which could lead to better treatments and technologies for everyone.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON STATE UNIVERSITY (nih funded) |
| Locations | 1 site (PULLMAN, UNITED STATES) |
| Trial ID | NIH-10783066 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of non-coding DNA in regulating gene expression, which is essential for advancements in biotechnology and human health. The project employs a novel technique called capped small RNA-seq (csRNA-seq) to accurately map transcription start sites (TSS) across various eukaryotic organisms. By identifying these TSSs, the research aims to uncover the functional DNA motifs that drive gene expression, even in the absence of direct sequence conservation. This approach allows for a comprehensive analysis of regulatory elements that may vary significantly across species.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or conditions influenced by gene regulation.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by genetic factors may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for manipulating gene expression, which may enhance treatments for various genetic disorders and diseases.
How similar studies have performed: Previous research has shown promise in understanding gene regulation through similar methodologies, indicating potential for success in this novel approach.
Where this research is happening
PULLMAN, UNITED STATES
- WASHINGTON STATE UNIVERSITY — PULLMAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUTTKE, SASCHA H. — WASHINGTON STATE UNIVERSITY
- Study coordinator: DUTTKE, SASCHA H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.