Investigating how nociceptor endocytosis affects inflammatory pain
The Role of the Nociceptor Endocytosis in Inflammatory Pain
This study is looking at how certain proteins can help manage inflammatory pain without using opioids, by testing local drug injections at injury sites to find safer ways to relieve pain for people who need it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-11093404 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of nociceptor endocytosis in managing inflammatory pain, particularly in the context of the opioid crisis. The team is exploring local drug injections at injury sites as a way to provide pain relief without the risks associated with opioids. They have identified specific proteins, such as the adaptin 2 alpha 2 subunit, that play a crucial role in pain signaling and have shown promising results in animal models. By targeting these proteins, the research aims to develop new, non-addictive pain relief methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing acute or chronic inflammatory pain who are seeking alternative pain management options.
Not a fit: Patients who do not experience inflammatory pain or those who are not responsive to local pain management techniques may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer, non-addictive pain relief medications for patients suffering from inflammatory pain.
How similar studies have performed: Previous research has shown success in targeting nociceptor mechanisms for pain relief, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Bhattacharjee, Arindam — State University of New York at Buffalo
- Study coordinator: Bhattacharjee, Arindam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.