Investigating how nociceptin affects heart and kidney function in rats with heart failure
Official title: CNS sites involved in the cardiovascular and renal effects of nociceptin in rats with heart failure
Funded at University of the Incarnate Word · NIH-10881923 · Data updated 2026-11-12
This study is looking at how a brain chemical called nociceptin affects heart and kidney health in rats with heart failure, to help find better ways to manage these conditions in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of the Incarnate Word NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $119,498 |
| NIH project number | 5R16GM145433-03 |
| Project ID | NIH-10881923 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for potential benefit from this research would be individuals suffering from heart failure or related cardiovascular conditions.
✕Less likely to help
Patients without heart failure or those who do not respond to nociceptin-related treatments may not benefit from this research.
What this research studies
This research explores the role of nociceptin, a peptide that interacts with specific receptors in the brain, in regulating heart and kidney functions. By studying conscious rats with heart failure, the researchers aim to understand how activating the ORL1 receptor can influence blood pressure, heart rate, and the excretion of water and sodium. The methodology involves observing the physiological changes in these animals to gather insights that could inform future treatments for heart failure. The findings may reveal new pathways for managing cardiovascular and renal health.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving heart and kidney function in patients with heart failure.
How similar studies have gone: While the specific role of nociceptin in heart failure is not extensively studied, similar approaches targeting opioid receptors have shown promise in other cardiovascular research.
Where this research is happening
-
University of the Incarnate Word
San Antonio, United States Active
Researchers
- Principal investigator: Gottlieb, Helmut B — University of the Incarnate Word
- Study coordinator: Gottlieb, Helmut B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.