Investigating how NLRP3 signals affect kidney injury during blood flow restoration.
Role of NLRP3 signals in ischemia/reperfusion-induced organ injury
This study is looking at how a specific immune system component called NLRP3 affects kidney cells when blood flow is temporarily stopped and then restored, with the goal of finding ways to protect kidneys from damage during surgeries or organ transplants for people who have acute kidney injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10853086 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of NLRP3, an innate immune receptor, in kidney cells during episodes of ischemia and reperfusion, which is when blood flow is temporarily cut off and then restored. The study aims to explore how NLRP3 signaling can lead to cell death or alternatively promote protective responses in renal tubular epithelial cells. By selectively targeting NLRP3 pathways, the researchers hope to prevent kidney damage while allowing the body to maintain necessary immune responses. This could lead to new treatments for patients suffering from acute kidney injuries, particularly those undergoing surgeries or organ transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients at risk of acute kidney injury, especially those undergoing surgeries or organ transplants.
Not a fit: Patients with chronic kidney disease or those not experiencing acute kidney injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect kidney function during critical medical situations.
How similar studies have performed: Previous research has shown that targeting NLRP3 can prevent kidney injury in experimental models, indicating a promising avenue for therapeutic development.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Mckay, Dianne B — Scripps Research Institute, the
- Study coordinator: Mckay, Dianne B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.