Investigating how NK cell memory affects HIV progression and vaccination
NK cell memory subsets and their impact on HIV disease progression and vaccination
This study is looking at how certain immune cells called natural killer (NK) cells can remember and fight HIV, which could help make better vaccines for people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10673142 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of natural killer (NK) cells in the immune response to HIV. It aims to explore how these cells can develop into long-lasting memory cells that specifically target HIV, which could enhance the effectiveness of vaccines. By studying the activation and differentiation of NK cells in response to natural HIV infection and adenovirus-based vaccination, the research seeks to identify mechanisms that could lead to improved vaccine strategies. Patients may benefit from insights that could lead to more effective HIV vaccines.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection who are interested in vaccine development.
Not a fit: Patients who are not infected with HIV and are not at risk of infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines against HIV, improving patient outcomes.
How similar studies have performed: Other research has shown promise in understanding NK cell responses in viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Machmach Leggat, Kawthar — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Machmach Leggat, Kawthar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.