Investigating how nitrogen metabolism affects smooth muscle cell behavior in arteries
The role of nitrogen metabolism in smooth muscle cell phenotypic plasticity
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF VIRGINIA · NIH-11001954
This study is looking at how certain changes in muscle cells in your arteries can lead to heart problems, and it hopes to find new ways to treat coronary artery disease that could help patients like you.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11001954 on ClinicalTrials.gov |
What this research studies
This research explores the role of nitrogen metabolism in the behavior of smooth muscle cells (SMCs) within arteries, particularly how these cells change from a healthy state to a more harmful one during the development of coronary artery disease (CAD). By analyzing genetic factors and cellular mechanisms, the study aims to uncover how SMCs contribute to plaque formation and atherosclerosis. The approach includes advanced techniques like RNA sequencing to identify molecular pathways that could be targeted for new therapies. Patients may benefit from insights that could lead to innovative treatments for CAD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for coronary artery disease, particularly those with a family history or genetic predisposition.
Not a fit: Patients who do not have risk factors for coronary artery disease or those with advanced CAD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that directly target the underlying causes of coronary artery disease.
How similar studies have performed: Other research has shown promise in targeting genetic factors related to coronary artery disease, indicating that this approach could yield significant insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PERRY, ROBERT NOAH — UNIVERSITY OF VIRGINIA
- Study coordinator: PERRY, ROBERT NOAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.