Investigating how nitro-fatty acids can protect the brain after a stroke
Role of nitro-fatty acids in BBB stabilization and post-stroke neurovascular protection
This study is looking at how a special type of fat called nitro-oleic acid might help protect the brain's blood barrier after a stroke, with the hope of finding better treatments for people recovering from strokes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11074521 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of nitro-fatty acids, specifically nitro-oleic acid, in stabilizing the blood-brain barrier (BBB) and providing neurovascular protection following a stroke. The study aims to identify mechanisms that prevent damage to the BBB, which is crucial for reducing inflammation and neuronal loss after a stroke. By examining how nitro-fatty acids can influence cell signaling and protect against injury, the research seeks to develop new therapeutic strategies for stroke survivors. Patients may benefit from insights that could lead to improved treatments for post-stroke complications.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older who have experienced a stroke.
Not a fit: Patients who have not suffered a stroke or those with conditions unrelated to stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery and quality of life for stroke survivors.
How similar studies have performed: Previous research has shown promising results with nitro-fatty acids in protecting against ischemia/reperfusion injury, indicating potential for success in this area.
Where this research is happening
Pittsburgh, United States
- Veterans Health Administration — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Yin, Kejie — Veterans Health Administration
- Study coordinator: Yin, Kejie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.