Investigating how nitric oxide affects proteins and bacteria
Mechanisms of novel biological nitrogen chemistries
This study is looking at how a molecule called nitric oxide affects proteins and bacteria, which could help us understand and improve treatments for diseases related to nerve damage and bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Central Florida NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project ID | NIH-10876332 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms by which nitric oxide (NO) influences protein function and bacterial behavior. It examines how NO can lead to protein nitration, which may be linked to neurodegenerative diseases, and explores the role of specific enzymes, particularly cytochromes P450, in these processes. By studying these interactions, the research aims to uncover new insights into how bacteria respond to nitrosative stress and how this knowledge could inform the development of new therapeutic strategies. Patients may benefit from advancements in treatments for conditions related to protein nitration and bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative disorders or those affected by bacterial infections linked to nitrosative stress.
Not a fit: Patients with conditions unrelated to protein nitration or bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases and bacterial infections by targeting the mechanisms of protein nitration.
How similar studies have performed: While the specific mechanisms being studied are novel, there has been prior research indicating that understanding protein nitration can lead to significant advancements in treating related conditions.
Where this research is happening
Orlando, United States
- University of Central Florida — Orlando, United States (Active)
Researchers
- Principal investigator: Caranto, Jonathan D — University of Central Florida
- Study coordinator: Caranto, Jonathan D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.