Investigating how Ninein affects anxiety relief from alcohol
The Role of Ninein in Ethanol Anxiolysis
This study is looking at how our genes, especially a protein called Ninein, might affect how alcohol helps reduce anxiety, using mice to see how different genetic backgrounds change their reactions to alcohol's calming effects, which could help us understand more about Alcohol Use Disorder and anxiety.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10898837 on NIH RePORTER |
What this research studies
This research explores the genetic factors that influence how alcohol can reduce anxiety, particularly focusing on a protein called Ninein. By studying mice with different genetic backgrounds, the researchers aim to understand how variations in Ninein affect the response to alcohol's calming effects. The study uses advanced techniques, including CRISPR, to manipulate genes and observe changes in behavior related to anxiety and alcohol consumption. This could lead to better understanding of Alcohol Use Disorder and its relationship with anxiety.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of anxiety disorders and alcohol use issues.
Not a fit: Patients who do not have anxiety disorders or alcohol dependence may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for individuals struggling with anxiety and alcohol dependence.
How similar studies have performed: Previous studies have shown promising results in understanding the genetic basis of anxiety and alcohol response, suggesting this approach could yield valuable insights.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Gnatowski, Emma — Virginia Commonwealth University
- Study coordinator: Gnatowski, Emma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.