Investigating how nickel exposure may cause lung cancer through genetic changes
Indirect Genotoxicity in Metal Carcinogenesis
This study is looking at how exposure to nickel, a metal found in many workplaces, can harm lung cells and potentially lead to cancer, with the goal of finding ways to better protect people's health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10747846 on NIH RePORTER |
What this research studies
This research explores the effects of nickel, a common industrial metal, on human lung cells to understand how it may lead to cancer. The study focuses on how nickel disrupts normal biochemical processes, leading to genetic damage that can cause tumors. By examining the metabolic changes and genetic abnormalities induced by nickel exposure, the researchers aim to uncover the mechanisms behind its carcinogenic effects. This knowledge could help improve public health responses and early detection of cancer risks associated with nickel.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of exposure to nickel, particularly those working in industries where nickel is prevalent.
Not a fit: Patients who have no history of nickel exposure or lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of lung cancer caused by nickel exposure.
How similar studies have performed: While the approach of investigating nonmutagenic carcinogens like nickel is relatively novel, similar studies have shown promising results in understanding other carcinogenic mechanisms.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Zhitkovich, Anatoly — Brown University
- Study coordinator: Zhitkovich, Anatoly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.