Investigating how nickel exposure may cause cancer through DNA damage
Nickel and toxic topoisomerase I products
This study is looking at how nickel, a common pollutant, might harm our DNA and lead to cancer, especially by examining cells from people who have been exposed to nickel, to help us understand the risks and find ways to prevent cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11002286 on NIH RePORTER |
What this research studies
This research explores the carcinogenic effects of nickel, a common environmental contaminant, particularly focusing on how it may induce DNA damage leading to cancer. The study aims to understand the mechanisms by which nickel ions interact with cellular processes, potentially causing chromosomal abnormalities and affecting DNA repair mechanisms. By examining cultured cells and lymphocytes from individuals exposed to nickel, the research seeks to uncover the unusual ways nickel may contribute to cancer development. This could provide insights into the risks associated with nickel exposure and inform future preventive measures.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with occupational exposure to nickel or those living in areas with high environmental nickel levels.
Not a fit: Patients who have no history of nickel exposure or related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of cancers associated with nickel exposure.
How similar studies have performed: Previous research has indicated potential mechanisms of carcinogenicity related to nickel, but this specific approach to understanding its genotoxic effects is relatively novel.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Zhitkovich, Anatoly — Brown University
- Study coordinator: Zhitkovich, Anatoly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.