Investigating how NgBR affects liver function and insulin resistance in diabetes
Official title: Role of NgBR in regulating hepatic gluconeogenesis and insulin resistance
Funded at NYU Long Island School of Medicine · NIH-11059136 · Data updated 2026-11-12
This study is looking at a protein called NgBR to see how it might help control insulin resistance and sugar production in the liver, which could lead to new ways to prevent or manage type 2 diabetes, especially for those at risk of obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | NYU Long Island School of Medicine NIH-funded |
| Lab location | 1 site (Mineola, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $546,459 |
| NIH project number | 5R01DK132056-04 |
| Project ID | NIH-11059136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of or currently have obesity-related type 2 diabetes.
✕Less likely to help
Patients who do not have obesity-related type 2 diabetes or those with other unrelated metabolic disorders may not benefit from this research.
What this research studies
This research focuses on understanding the role of NgBR, a protein that may help regulate insulin resistance and glucose production in the liver. By studying how NgBR interacts with adiponectin and the AMPK pathway, the researchers aim to uncover mechanisms that could prevent obesity-related type 2 diabetes (T2D). The study involves animal models to observe changes in glucose levels and liver function when NgBR is altered. If successful, this research could lead to new strategies for managing or preventing T2D.
Why it matters
Potential benefit: If successful, this research could provide new insights into preventing or treating type 2 diabetes, potentially improving the lives of millions affected by this condition.
How similar studies have gone: Previous research has shown promising results in understanding the role of adiponectin and AMPK in diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
NYU Long Island School of Medicine
Mineola, United States Active
Researchers
- Principal investigator: Miao, Qing — NYU Long Island School of Medicine
- Study coordinator: Miao, Qing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.