Investigating how NFATC1 affects heart rhythm and excitability
A Novel Role for NFATC1 in Modulating Cardiac Excitability
This study is looking at how a gene called NFATC1 affects heart rhythm problems like atrial fibrillation, and it aims to find out if changes in this gene can help us understand and treat this condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10653775 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a gene called NFATC1 in atrial fibrillation (AF), a common heart rhythm disorder. Researchers will explore how mutations in NFATC1 contribute to changes in heart cell behavior and excitability, which may lead to AF. The study will utilize various models, including human cell cultures and zebrafish, to investigate the molecular mechanisms involved. By identifying how NFATC1 influences heart function, the research aims to uncover new insights into AF and potential treatment targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of atrial fibrillation or those at high risk for developing this condition.
Not a fit: Patients without any history of heart rhythm disorders or those not at risk for atrial fibrillation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atrial fibrillation, improving heart health for many patients.
How similar studies have performed: Other research has shown promising results in understanding genetic factors in atrial fibrillation, making this approach both relevant and potentially impactful.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Tristani-Firouzi, Martin — University of Utah
- Study coordinator: Tristani-Firouzi, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.