Investigating how new pyrimidine production affects heart remodeling
Role of de novo pyrimidine biosynthesis in pathological cardiac remodeling
This study is looking at how the heart makes certain building blocks when it's under stress from high blood pressure or reduced blood flow, and it hopes to find ways to help improve heart function for people dealing with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-11016963 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of de novo pyrimidine biosynthesis in the heart's response to stress from high blood pressure and ischemic conditions. It aims to uncover how these metabolic changes contribute to the progression of heart failure, particularly after events like myocardial infarction. By studying the heart's adaptive and maladaptive responses, the research seeks to identify potential therapeutic targets that could improve heart function. Patients may benefit from insights gained into how metabolic alterations influence heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with a history of hypertension or ischemic heart disease who are at risk for heart failure.
Not a fit: Patients with stable heart conditions not related to hypertension or ischemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse heart failure in patients with high blood pressure or ischemic heart disease.
How similar studies have performed: Previous studies have indicated that metabolic alterations play a significant role in heart failure, suggesting that this research could build on established findings.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Wang, Zhao — Beckman Research Institute/city of Hope
- Study coordinator: Wang, Zhao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.