Investigating how neutrophils contribute to inflammatory diseases
The Neutrophil Lineage in Inflammasomopathies
This study is looking at how a type of white blood cell called neutrophils might be causing inflammation in people with cryopyrin associated periodic syndromes (CAPS) and other similar conditions, to help find better treatments for these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10894797 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of neutrophils in cryopyrin associated periodic syndromes (CAPS) and other inflammatory diseases. It aims to explore how neutrophils, rather than monocytes and macrophages, may drive inflammation in these conditions. The study will involve analyzing cells from patients with CAPS and using mouse models to investigate the biochemical mechanisms that regulate inflammation in neutrophils. By examining the genetic and molecular factors involved, the research seeks to uncover new insights into the treatment of these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with cryopyrin associated periodic syndromes and other NLRP3-dependent inflammatory diseases.
Not a fit: Patients without a diagnosis of CAPS or related inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from CAPS and related inflammatory conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of neutrophils in inflammation, but this specific approach is relatively novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Croker, Ben Adam — University of California, San Diego
- Study coordinator: Croker, Ben Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.