Investigating how neutrophils contribute to blood flow issues in Alzheimer's disease
Official title: Neutrophil-driven vascular inflammation in VCID and Mixed Alzheimer's Disease
Funded at University of Miami Coral Gables · NIH-11053757 · Data updated 2026-11-12
This study is looking at how certain immune cells called neutrophils might affect blood flow and thinking skills in people with Alzheimer's disease and related conditions, using special imaging techniques in mice to find ways to help improve brain function for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami Coral Gables NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $631,577 |
| NIH project number | 1R01NS141137-01 |
| Project ID | NIH-11053757 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive impairment related to vascular issues.
✕Less likely to help
Patients with cognitive impairment not related to Alzheimer's disease or vascular issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of neutrophils, a type of immune cell, in causing blood flow reductions and cognitive decline in Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID). The researchers will use advanced imaging techniques to observe neutrophil behavior and blood flow in mouse models of AD over time. They will also analyze neutrophil characteristics at a single-cell level to identify specific subpopulations that may worsen disease progression. By uncovering the mechanisms behind neutrophil activation and its effects on blood vessels, this research aims to provide insights into potential therapeutic targets for improving cognitive function in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and cognitive function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has indicated that targeting immune cell interactions with blood vessels can improve outcomes in neurodegenerative diseases, suggesting a promising avenue for this investigation.
Where this research is happening
-
University of Miami Coral Gables
Coral Gables, United States Active
Researchers
- Principal investigator: Bracko, Oliver — University of Miami Coral Gables
- Study coordinator: Bracko, Oliver
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.