Investigating how neutrophils affect tumor growth and treatment resistance in cancer.
Engineer Biomimetic Microfluidic Models to Investigate and Reprogram Tumor Associated Neutrophils for Cancer Therapy
This study is looking at how a type of immune cell called neutrophils affects brain tumors like glioblastoma, with the hope of finding new ways to make cancer treatments work better for patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10884311 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of neutrophils, a type of immune cell, in the development and progression of brain tumors like glioblastoma. By using advanced microfluidic models and human stem cells, the researchers aim to study how these cells behave in different stages of tumor growth and how they might contribute to resistance against cancer therapies. The goal is to uncover mechanisms that could lead to new treatments targeting neutrophils to improve cancer therapy outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma or other types of cancer where neutrophils play a significant role in tumor progression.
Not a fit: Patients with cancers that do not involve neutrophils or those who are not eligible for experimental therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance the effectiveness of existing cancer treatments by targeting neutrophils.
How similar studies have performed: Previous studies have shown that targeting immune cells can improve cancer treatment outcomes, suggesting that this approach may hold promise.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Bao, Xiaoping — Purdue University
- Study coordinator: Bao, Xiaoping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.