Investigating how neutrophil traps can be stabilized to improve treatment for inflammatory diseases
NET stabilization: mechanistic and therapeutic studies studying the role of NETs in thromboinflammatory disease
This study is looking at how to make certain immune traps in your body work better to fight infections without causing too much harm, which could help people with conditions like sepsis and sickle cell disease feel better and live longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11062950 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of neutrophil extracellular traps (NETs) in inflammatory diseases such as sepsis and sickle cell disease. It aims to explore a novel approach of stabilizing these traps to enhance their ability to capture pathogens while minimizing tissue damage. By using a specific antibody that targets a protein involved in NET stabilization, the research seeks to improve patient outcomes in conditions where NETs play a detrimental role. Patients may benefit from new therapeutic strategies that leverage this stabilization to reduce inflammation and improve survival rates.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from sepsis or sickle cell disease who are experiencing severe inflammatory responses.
Not a fit: Patients with conditions unrelated to neutrophil activity or those not experiencing significant inflammatory responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance the body's ability to fight infections while reducing harmful inflammation.
How similar studies have performed: Previous research has shown promise in similar approaches, indicating potential for success in stabilizing NETs for therapeutic purposes.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Gollomp, Kandace — Children's Hosp of Philadelphia
- Study coordinator: Gollomp, Kandace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.