Investigating how neutrophil receptors affect sepsis
Neutrophil A2A receptors in sepsis
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10886573
This study is looking at how certain receptors on immune cells called neutrophils work during sepsis, a serious infection, to see if changing these receptors can help improve the body's ability to fight the infection and reduce inflammation, with the hope of finding better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10886573 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of A2A adenosine receptors on neutrophils during sepsis, a severe infection that can lead to organ failure and death. The study examines how these receptors influence neutrophil functions, such as their ability to fight bacteria and manage inflammation. By using animal models, researchers will explore the effects of manipulating these receptors to potentially improve neutrophil responses in sepsis. The goal is to identify new therapeutic targets that could lead to better treatments for patients suffering from this critical condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients diagnosed with sepsis or those at high risk of developing sepsis.
Not a fit: Patients with non-infectious causes of organ failure or those who are not critically ill may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response in sepsis, potentially reducing mortality rates.
How similar studies have performed: Previous research has shown that targeting similar pathways in immune responses can lead to significant improvements in treatment outcomes for critically ill patients.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HASKO, GEORGE — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: HASKO, GEORGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.