Investigating how neutrophil extracellular traps affect pancreatic cancer
Role of Neutrophil Extracellular Traps in Pancreatic Cancer
This study is looking at how certain traps made by immune cells might help a tough type of pancreatic cancer grow and resist treatment, and it aims to find new ways to fight this cancer by focusing on a specific enzyme involved in making those traps.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project ID | NIH-10916366 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of neutrophil extracellular traps (NETs) in pancreatic ductal adenocarcinoma (PDAC), a highly aggressive form of cancer. The study aims to explore how these traps contribute to the tumor's fibrotic and immunosuppressive environment, which hinders effective treatment. By examining the mechanisms through which NETs promote tumor growth and resistance to therapy, the researchers hope to identify new therapeutic targets, particularly the enzyme PAD4, which is crucial for NET formation. The approach includes using genetically modified mice to assess the impact of inhibiting NETs on tumor progression and immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma who are seeking innovative treatment options.
Not a fit: Patients with other types of cancer or those not diagnosed with pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the effectiveness of therapies for pancreatic cancer patients.
How similar studies have performed: Previous research has shown promising results in targeting neutrophil extracellular traps in other cancer types, indicating potential for success in this novel approach.
Where this research is happening
Morgantown, United States
- West Virginia University — Morgantown, United States (Active)
Researchers
- Principal investigator: Boone, Brian a — West Virginia University
- Study coordinator: Boone, Brian a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.