Investigating how neurotrophins and glutamate interact in the brain
Molecular and Synaptic Mechanisms of Neurotrophin-glutamate Crosstalk
This study is looking at how certain brain chemicals work together to help us learn and remember, and it hopes to find new ways to improve treatments for brain-related conditions that affect mood and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10907627 on NIH RePORTER |
What this research studies
This research explores the interactions between neurotrophins, specifically brain-derived neurotrophic factor (BDNF), and neurotransmitters like glutamate in the brain. It aims to understand how these molecules communicate and influence synaptic plasticity, which is crucial for learning and memory. By examining the signaling pathways involved, the study seeks to uncover new mechanisms that could lead to better treatments for neurodegenerative and neuropsychiatric disorders. Patients may benefit from insights gained about how these interactions affect brain function and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative or neuropsychiatric conditions who may benefit from improved understanding and treatment options.
Not a fit: Patients with acute injuries or conditions unrelated to neurodegenerative or neuropsychiatric disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative and neuropsychiatric disorders.
How similar studies have performed: While the specific approach of investigating neurotrophin and neurotransmitter crosstalk is relatively novel, similar studies have shown promising results in understanding synaptic mechanisms.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Levitz, Joshua — Weill Medical Coll of Cornell Univ
- Study coordinator: Levitz, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.