Investigating how neurotrophins affect learning and memory in the brain
Neurotrophins and Consolidation of Learning-Related Synaptic Plasticity
['FUNDING_R01'] · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · NIH-10890646
This study is looking at how a special protein called BDNF helps our brain cells communicate and learn better, using a simple sea creature as a model, to find out more about how we remember things and how this might help people with brain-related conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10890646 on ClinicalTrials.gov |
What this research studies
This research explores the role of neurotrophins, particularly Brain-Derived Neurotrophic Factor (BDNF), in synaptic plasticity, which is crucial for learning and memory. Using a model system from Aplysia, the study aims to understand how these molecules function at the cellular level, including their release and interaction at synapses. By examining the feedback mechanisms involved in synaptic signaling, the research seeks to uncover new insights into how learning processes are consolidated in the brain, which could have implications for various neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related cognitive impairments.
Not a fit: Patients with non-neurological conditions or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving memory and learning in patients with Alzheimer's disease and other cognitive disorders.
How similar studies have performed: Previous research has shown promising results in understanding neurotrophins' roles in synaptic plasticity, indicating that this approach has potential for significant findings.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAWKINS, ROBERT D — NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- Study coordinator: HAWKINS, ROBERT D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease