Investigating how neurons in the hippocampus are selected for memory encoding.
Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representations
This study is looking at how certain brain cells in the hippocampus work together to help us form memories, using awake mice to see how these cells are chosen to create memory groups, which could help us understand more about how we learn and remember things.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10979150 on NIH RePORTER |
What this research studies
This research explores the mechanisms by which individual neurons in the hippocampus are recruited to form memory coding ensembles. Using advanced experimental techniques, the study monitors specific neurons and their subcellular activities in awake mice. By combining these observations with circuit modeling, the research aims to uncover the dynamics of neuron selection during contextual memory formation, focusing on both excitatory and inhibitory cell types. This work could provide insights into the fundamental processes of memory and learning.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals with cognitive impairments or memory disorders.
Not a fit: Patients with no cognitive issues or those not interested in neuroscience may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of memory formation, potentially leading to new treatments for memory-related disorders.
How similar studies have performed: Other research in neuroscience has shown success in understanding neuron behavior and memory encoding, making this approach promising yet still innovative.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Losonczy, Attila — Columbia University Health Sciences
- Study coordinator: Losonczy, Attila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.