Investigating how neuron-specific genes regulate Sortilin-1 in Alzheimer's and Frontotemporal Dementia
Official title: Regulation of Sortilin-1 by Neuron-Specific Genes; implications for AD and FTD
Funded at University of New Mexico Health Scis Ctr · NIH-10871244 · Data updated 2026-11-12
This study is looking at how a protein called Sortilin-1 might affect Alzheimer's disease and Frontotemporal Dementia, hoping to find new ways to help treat these conditions by understanding how it works in the brain.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $419,375 |
| NIH project number | 1R21AG086934-01 |
| Project ID | NIH-10871244 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or Frontotemporal Dementia.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's or Frontotemporal Dementia may not benefit from this research.
What this research studies
This research focuses on understanding the role of Sortilin-1 (SORT1) in Alzheimer's disease (AD) and Frontotemporal Dementia (FTD). It aims to explore how neuron-specific genes interact with SORT1, which has been identified as a significant risk factor for late-onset AD. The study will involve molecular analyses to uncover the mechanisms of SORT1 processing and its implications for disease pathology. By examining these interactions, the research seeks to provide insights into potential therapeutic targets for AD and FTD.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease and Frontotemporal Dementia.
How similar studies have gone: Previous research has shown promising results in understanding the role of SORT1 in Alzheimer's disease, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Weick, Jason P — University of New Mexico Health Scis Ctr
- Study coordinator: Weick, Jason P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.