Investigating how neuron contact influences the development of brain support cells called astrocytes.
Official title: How does neuronal contact mediate astrocyte transcriptional maturation?
Funded at Duke University · NIH-10892070 · Data updated 2026-11-12
This study is looking at how brain support cells called astrocytes grow and develop when they interact with nerve cells, which could help us understand more about brain health and how problems in these processes might lead to neurological issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $41,865 |
| NIH project number | 5F31NS134252-02 |
| Project ID | NIH-10892070 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological conditions that may involve astrocyte dysfunction, such as autism spectrum disorder.
✕Less likely to help
Patients with conditions unrelated to astrocyte function or those who do not have neurological disorders may not benefit from this research.
What this research studies
This research explores the role of neuronal contact in the maturation of astrocytes, which are crucial support cells in the brain. By examining how astrocytes develop when they are in contact with neurons, the study aims to uncover the molecular mechanisms that drive their growth and function. The researchers will utilize advanced techniques like chromatin immunoprecipitation sequencing to analyze changes in gene expression and histone modifications in astrocytes. This could provide insights into how disruptions in these processes might contribute to neurological conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for brain disorders by enhancing our understanding of astrocyte function and development.
How similar studies have gone: Previous research has shown promising results in understanding the role of astrocytes in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Savage, Justin — Duke University
- Study coordinator: Savage, Justin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.