Investigating how neuromodulation affects movement and behavior in the brain.
Neuromodulation in the striatum
This study looks at how certain brain chemicals, especially dopamine, affect movement and decision-making, and it aims to find out how imbalances in these chemicals might contribute to movement disorders like Parkinson's disease, which could help develop better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11047758 on NIH RePORTER |
What this research studies
This research focuses on the striatum, a key brain region involved in controlling movement and decision-making. It examines how different neuromodulators, particularly dopamine, influence the balance between two pathways that regulate motor function. By understanding these mechanisms, the research aims to uncover how disruptions in this balance can lead to neurological disorders like Parkinson's disease. Patients may benefit from insights that could lead to new treatments for movement-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with movement disorders such as Parkinson's disease or Huntington's disease.
Not a fit: Patients with non-neurological conditions or those without movement-related symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neurological disorders that affect movement and behavior.
How similar studies have performed: Previous research has shown promising results in understanding the role of neuromodulators in motor control, suggesting that this approach could yield significant insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Zhong, Haining — Oregon Health & Science University
- Study coordinator: Zhong, Haining
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.